The effect of estrogen therapy on cerebral metabolism in diabetic female rats

The impact of estrogen on brain function, especially in individuals with diabetes, remains uncertain. This study aims to compare cerebral glucose metabolism levels intact rats, ovariectomized (OVX) and 17β-estradiol (E2)-treated OVX diabetic female rats. Sixteen rats were administered a single intraperitoneal injection 70 mg/kg streptozotocin (STZ) induce diabetes (intact, n = 6; OVX, OVX+E2-treated, 4). Additionally, 18 received an equivalent solvent dose via 6). After 4 weeks STZ or administration, positron emission tomography scans 18F-fluorodeoxyglucose (18F-FDG) employed assess metabolism. exhibited substantial reductions 18F-FDG uptake across all regions (all P < 0.01), contrast the control Moreover, + E2-treated displayed more pronounced decreases amygdala hippocampus compared (P 0.05). These findings suggest that creates environment wherein exacerbates neuropathology intensifies neuronal activity.